CAS Number: 960129-66-2Molecular Weight: 660Salt Form: TFAPurity: >95%Sequence (3-letter): Asn-Asn-Trp-Asn-Asn-OHSequence (1-letter): NNWNN-OHStorage: -20 °C or below

Extracellular death factor (EDF) is a linear pentapeptide that activates the cell death pathway in a subset of communicating cells. Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. It is sensitive to extreme pH, high temperatures, and other cellular stress. EDF has been shown to trigger cell death at 2.5 ng/ml which significantly reduces population size in some E. coli cultures.

References

Belitsky M, Avshalom H, Erental A, Yelin I, Kumar S, London N, Sperber M, Schueler-Furman O, Engelberg-Kulka H (2011) “The Escherichia coli Extracellular Death Factor EDF Induces the Endoribonucleolytic Activities of the Toxins MazF and ChpBK” Mol. Cell 41 (6) 625-635